A new technique creates greater fidelity in bioprinting functional human tissues: Engineers take on the light-scattering problem in a leading form of 3D-bioprinting

Researchers at the University of California San Diego have made significant advances in bioprinting 3D-engineered tissues. This technology has great potential for biomedical applications, such as drug testing and development, organ transplations, and regenerative medicine. The team reduced light-scattering effects by tenfold, allowing them to print with high cell densities and high resolution thanks to the contrast agent iodixanol. This approach introduces a few novel technical innovations, including a hollow organic vascular network embedded in a cell-laden thick tissue, enabling it for perfused and long-term culture. The team continues to work on optimizing its materials system and bioprinting parameters for functional thick tissue fabrication. This breakthrough could have far-reaching implications for tissue and organ transplants and replacements in human subjects.

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