In this research, scientists studied how a protein called SREBP-1c is involved in making fatty acids in the body. They found that SREBP-1c is cut by a protein called RHBDL4, and this cutting process is influenced by different types of fatty acids. They also discovered that another group of proteins called the VCP complex helps to move the cut SREBP-1c out of the endoplasmic reticulum. In mice with a gene deficiency for RHBDL4 and fed a high-fat, high-cholesterol diet, the cutting of SREBP-1c was reduced, which improved the way their liver processed fat.
This study is important because it helps us understand how the body balances its fat levels, and it could lead to new treatments for problems related to how the body deals with fat. The research was supported by grants from the Ministry of Science, Education, Culture, and Technology of Japan, the Japan Agency for Medical Research and Development, and the Ono Medical Research Foundation.
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