Scientists found out why the skin lesions from cutaneous leishmaniasis don’t cause pain. They conducted research on mice with leishmaniasis and discovered that the parasites which cause the disease prevent pain perception, likely in order to delay treatment and help their survival. This research might lead to new painkillers.

The scientists found molecules in the infected skin that are known to block pain and also discovered pathways linked to relieving pain. These molecules are used by the parasite for nutrition, but it is not fully understood how they influence pain sensation. The research also worked on developing a skin test for immunity to leishmaniasis and tested it on hamsters. This test will help in disease surveillance.

The research on leishmaniasis was published in the journal “iScience”, while the research on the skin test was published in “Nature Communications”. The study was supported by the Global Health Innovative Technology Fund, the Canadian Institutes of Health Research, the FDA, the National Institutes of Health, NAIAD and the Fonds de recherche du Quebec-Sante. Mobile metabolites were found to be responsible for lack of pain perception, leading to the development of a possible painkiller, also, a way to diagnose the immunity for leishmaniasis.

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By hassani

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