As we get older, our bodies and our stem cells undergo a process called senescence, where they degenerate and stop producing important biomolecules. This is a problem when we want to use these cells for therapeutic purposes. Current methods of removing older cells from cultures are not very effective, so researchers are looking for ways to prevent cells from entering the senescent state in the first place. One strategy is to condition the environment that the stem cells are in, using antioxidants to control the oxidative state. However, delivering antioxidants to the cells can be difficult because current methods have limitations, such as inconsistent drug release.
A new study by researchers at the University of Illinois describes a more reliable method of delivering antioxidants to stem cells. They developed polymer-stabilized crystals that dissolve at a slower rate, allowing for a more uniform and extended release of the drug. This new method improves the effectiveness and duration of the drug’s effects. The researchers believe that this approach could be used not only for stem cells but also for other types of cells important in medicine and therapeutics. The crystals could also potentially be used to deliver other drugs directly to the target tissue of a patient.
The researchers hope that this technology can be further improved and applied to various drug delivery applications. They believe it has great potential in the field of biomanufacturing and could lead to a larger harvest of biomolecules for therapeutic purposes. It could also be used in patient-derived stem cell treatments, where the patient’s own cells are used to create the needed biomolecules. Overall, this new method offers exciting possibilities for improving medical treatments and therapies.
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